TABLE 1.
In vitro pharmacokinetic and CYP450 profile of VU0364770
| Intravenous Clearance (Cassette) | |
|---|---|
| T1/2, min | 22.1 |
| Cl, ml/min/kg | 165 |
| Vss, l/kg | 2.92 |
| CYP450 1A2, μM | 0.55 |
| CYP450 2C9 | >30 |
| CYP450 2D6 | >30 |
| CYP450 3A4 | >30 |
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