Table 3.

Drug susceptibility results and genotypic characterization of the 10 M. tuberculosis isolates with a nonsynonymous pncA mutation from 2007

Age of patient (yrs)	Sex of patient (M/F)	Characteristic of isolate
		VNTR type	Pyrazinamide susceptibilityc	Resistance to other drugsd	pncA mutation
					Nucleotide change	Amino acid change
34	F	9001812	S	H, RFB, E, SPT	G to A at 82	Ala28Thr
42	F	9001951	S		C to T at 127	His43Tyr
29	M	9002014	S	H, RFB, E, SPT	C to G at 147	Asp49Glu
46	F	9000148	S		G to A at 371	Gly124Asp
—a	—a	9001879	R	Unknowna	C to G at 102	Frame shift
48b	F	9002249	R	H, RFB, E, SPT	A to C at 226	Thr76Pro
48b	F	9002249	R	H, RFB, E, SPT	A to C at 226	Thr76Pro
31	F	9002426	R	H, RFB, E, SPT	C to T at 169	His57Tyr
48b	F	9002249	R	H, RFB, E, SPT	A to C at 226	Thr76Pro
48b	F	9002249	R	H, RFB, E, SPT	A to C at 226	Thr76Pro

^a—, anonymous research isolate from foreign TB reference center.

^bDifferent isolates from the same patient.

^cS, susceptible; R, resistant.

^dDrug names: H, isoniazid; RFB, rifampin; E, ethambutol; SPT, streptomycin.