Table 3.
Detection of CMV gB and gH genotypes in DBS from children with hearing impairment at the age of 3 to 5 years (22)b
| DBS from newborn | gB genotype | gH genotype | CMV IE load in DBS (log10 copies/ml whole blood) | Symptom(s) at birth | Developmental scorea | Severity of hearing loss |
|---|---|---|---|---|---|---|
| 1 | 3 | 2 | 4.1 | None | 59 | 60–90 dB |
| 2 | ND | ND | 3.3 | None | 84 | 40–60 dB |
| 3 | 4 | 1 | 4.9 | None | 72 | >90 dB (CI) |
| 4 | 2 | 2 | 3.6 | None | 68 | 60–90 dB |
| 5 | 3 | 2 | 5.9 | IUGR, microcephaly, seizures | 30 | >90 dB (CI) |
| 6 | 2 | 1 | 5.3 | IUGR, petechiae, hepatosplenomegaly, jaundice, thrombocytopenia | 50 | >90 dB (CI) |
| 7 | 4 | 1 | 5.3 | IUGR, jaundice, microcephaly | Unknown | >90 dB |
| 8 | 2 | 1 | <3.0 | None | 82 | >90 dB (CI) |
| 9 | ND | ND | 3.6 | Cataract | 56 | >90 dB (CI) |
a
The general development score is a summary score that provides an overall index of development by including 10 of the most age-discriminating items from each scale of the Child Development Inventory. The Child Development Inventory is a standardized instrument (parent questionnaire) designed to assess the social development, language development, and motor development of young children. Higher scores indicate better development.
b
Abbreviations: IE, immediate-early antigen; DBS, dried blood spots; gB, glycoprotein B; gH, glycoprotein H; CI, cochlear implant; IUGR, intrauterine growth retardation; ND, not detected.