Table 2.
Final multivariable logistic regression models for factors associated with clinical and microbiological success
| Model description | Independent variable | Parameter estimate (SE) | Odds ratio (95% CI) | P valued |
|---|---|---|---|---|
| Model 1 for clinical response | Intercept | −7.30 (2.28) | ||
| Albumina | 2.56 (0.82) | 13.0 (2.59, 65.1) | <0.001 | |
| fAUC0–24:MIC ratio of ≥0.9 | 2.13 (0.86) | 8.42 (1.55, 45.7) | 0.008 | |
| Model 2 for microbiological response | Intercept | −7.76 (2.56) | ||
| Albumina | 3.05 (1.03) | 21.0 (2.82, 157) | <0.001 | |
| Non-VAPb | −2.15 (0.78) | 8.59 (1.85, 39.8) | 0.003 | |
| Model 3 for microbiological response | Intercept | −8.30 (2.73) | ||
| Albumin | 3.67 (1.11) | 39.2 (4.39, 350) | 0.001 | |
| MIC, 0.5 or 1.0 mg/literc | 1.77 (1.02) | 5.85 (0.79, 43.2) | 0.16 | |
| MIC, >1.0 mg/literc | −1.35 (0.93) | 0.259 (0.041, 1.62) |
a
Parameter estimates and odds ratios for albumin correspond to a 1 unit increase.
b
Reference group represents the non-VAP patients.
c
Reference group represents a MIC of <0.5 mg/liter.
d
Based upon the likelihood ratio test. For model 3, Wald P values for MIC groups of 0.5–1.0 and >1.0 relative to 0.5 mg/liter were 0.08 and 0.14, respectively.