Table 1.
Overview of antiretroviral compounds
| Compound | Abbreviation | Drug class | Target | Molecular wt | Chemical type |
|---|---|---|---|---|---|
| BMS-806 | BMS-806 | Entry inhibitor | CD4-binding site on gp120 | 406 | Small molecule |
| M48-U1 | M48-U1 | Entry inhibitor | CD4-binding site on gp120 | 3,048 | Miniprotein |
| CD4-immunoglobulin | CD4-IgG2 | Entry inhibitor | CD4-binding site on gp120 | 200,000 | Protein |
| Neutralizing antibody b12 | b12 | Entry inhibitor | CD4-binding site on gp120 | 150,000 | Protein |
| Griffithsin | GRFT | Entry inhibitor | Glycans on gp120 | 12,700 | Lectin |
| Enfuvirtide | T-20 | Entry inhibitor | gp41 | 4,492 | Peptide |
| C34-cholesterol | C34-chol | Entry inhibitor | gp41 | 5,021 | Peptide plus cholesterol |
| Maraviroc | MVC | Entry inhibitor | CCR5 coreceptor | 514 | Small molecule |
| Saquinavir | SQV | Protease inhibitor | Protease | 767 | Small molecule |
| Lopinavir | LPV | Protease inhibitor | Protease | 629 | Small molecule |
| Dapivirine | TMC120 | Nonnucleoside reverse transcriptase inhibitor | Reverse transcriptase | 329 | Small molecule |
| UC781 | UC781 | Nonnucleoside reverse transcriptase inhibitor | Reverse transcriptase | 336 | Small molecule |
| Tenofovir | TFV | Nucleotide reverse transcriptase inhibitor | Reverse transcriptase | 287 | Small molecule |
| Raltegravir | RAL | Integrase strand transfer inhibitor | Integrase | 444 | Small molecule |