Table 1.
Parameter means, medians, and standard deviations from the mathematical model fitted to rabbit PK and PC data
| Parametera | Mean | Median | SD |
|---|---|---|---|
| SCL (liters/h) | 0.163 | 0.208 | 0.079 |
| Vc (liters) | 0.503 | 0.509 | 0.006 |
| kcb (h−1) | 1.192 | 1.284 | 0.172 |
| kbc (h−1) | 0.469 | 0.621 | 0.234 |
| kcp (h−1) | 7.948 | 6.572 | 4.195 |
| kpc (h−1) | 13.045 | 16.308 | 7.638 |
| Vbrain (liters) | 7.891 | 7.049 | 6.785 |
| Kgmax (log10 CFU/g/h) | 0.137 | 0.108 | 0.040 |
| Hg | 8.245 | 9.772 | 3.227 |
| C50g (mg/liter) | 0.462 | 0.457 | 0.108 |
| POPMAX (CFU/g) | 29,474,300 | 3,022,935 | 43,887,300 |
| Kkmax (log10 CFU/g/h) | 0.188 | 0.077 | 0.207 |
| Hk | 5.263 | 7.130 | 2.777 |
| C50k (mg/liter) | 2.569 | 2.690 | 0.388 |
| Initial condition (CFU/g) | 18.83 | 22.87 | 8.02 |
SCL is the clearance. Vc and Vbrain are the volumes of the central compartment and brain, respectively. kcp, kpc, kck, and kkc are the first-order rate constants that connect the respective compartments. Kgmax is the maximal rate of growth. POPMAX is the theoretical maximal density within the brain. Hg is the slope function for the suppression of growth. C50g is the amount of drug in the brain where there is half-maximal suppression of growth. Kkmax is the maximal rate of kill. Hk is the slope functions for the fungal kill. C50k is the concentration of anidulafungin in the brain at which fungal killing is half-maximal. The initial condition is the fungal density in the brain immediately postinoculation.