Fig 2.

Correspondence between polymorphisms in the P. malariae dhfr gene and equivalent residues known to be related to pyrimethamine resistance in the P. falciparum and P. vivax dhfr genes. For P. falciparum and P. vivax, codons resulting from nonsynonymous mutations related to pyrimethamine resistance are indicated by boldface and shading. For P. malariae, codons likely related to pyrimethamine resistance are indicated by boldface and shading, while those close to SNP involved in P. falciparum or P. vivax pyrimethamine resistance are shown in boldface only. P. malariae codons in italics correspond to mutations described previously by Tanomsing et al. (37).