Table 1.
Characteristics of patients and healthy volunteers
| Parametera | Value for group |
||
|---|---|---|---|
| Pregnant patients | Nonpregnant patients | Healthy women | |
| No. of patients | 53 | 13 | 12 |
| Median age (yr) (range) | 28 (18–41) | 33 (28–49) | 24 (21–32) |
| Median gestational age of fetus (wk) (range) | 29.1 (11.9–39) | ||
| Median total body wt (kg) (range) | 76 (47–178) | 67 (47–112) | 61 (45–84) |
| Median lean body wt (kg) (range) | 45 (32–68) | 43 (33–57) | 40 (30–51) |
| Median ht (cm) (range) | 163 (138–175) | 160 (155–173) | 160 (150–176) |
| Median creatinine clearance (ml/min) (range) | 127 (45–229) | 83 (37–115) | 91 (69–109) |
| No. of patients of ethnicity | |||
| African American | 17 | 2 | 0 |
| Asian | 3 | 1 | 1 |
| Caucasian (non-Hispanic) | 28 | 6 | 8 |
| Hispanic | 5 | 3 | 1 |
| Pacific Islander | 0 | 1 | 2 |
| No. of patients with infection | |||
| Upper or lower RTI | 30 | 11 | |
| PROMs | 14 | 0 | |
| Chlamydia | 8 | 0 | |
| Skin | 1 | 2 | |
| No. of patients on azithromycin oral regimen | |||
| 500 or 1,000 mg on day 1 and 250 mg daily for 4 days | 34 | 11 | 12 |
| 1,000-mg single dose | 8 | 0 | 0 |
| Other | 11 | 2 | 0 |
| No. of patients on concurrent medicationb | |||
| Albuterol | 3 | 1 | 0 |
| Amoxicillin | 14 | 0 | 0 |
| Ampicillin | 13 | 0 | 0 |
| Betamethasone | 6 | 0 | 0 |
| Ceftriaxone | 7 | 0 | 0 |
| Fluoxetine | 3 | 0 | 0 |
| Fluticasone | 3 | 0 | 0 |
| Gabapentin | 0 | 2 | 0 |
| Insulin | 4 | 1 | 0 |
| Oral contraceptives | 0 | 4 | 6 |
| Prednisone | 2 | 1 | 0 |
a
Abbreviations: PROMS, premature rupture of membranes; RTI, respiratory tract infection.
b
Excludes vitamins, oral iron, and medications received by 2 or fewer participants.