Table 2.
Population pharmacokinetic parameters and bootstrap results from the final covariate model
| Parametera | Value |
|||
|---|---|---|---|---|
| Final model |
Bootstrap (n = 1,000) |
|||
| Estimate | RSE (%) | Median | 2.5th–97.5th percentiles | |
| ka (h−1) | 0.8 | |||
| tlag (h) | 1.3 | 0.1 | 1.3 | 1.0–1.6 |
| CL/F (liters/h/50-kg LBW) | 134 | 12 | 135 | 85–176 |
| Effect of pregnancy in non-African Americans or effect of coadministration of oral contraceptives | −51 | 28 | −44 | −78–−4 |
| CLD-P1/F (liters/h) | 401 | 14 | 398 | 235-609 |
| CLD-P2/F (liters/h) | 120 | 15 | 115 | 35–208 |
| Effect of pregnancy in non-African Americans | −78 | 31 | −72 | −140–29 |
| Vc/F (liters) | 456 | 11 | 436 | 189–716 |
| VP1/F (liters) | 1,560 | 29 | 1,630 | 925–3,629 |
| VP2/F (liters) | 16,100 | 16 | 17,400 | 6,124–31,837 |
| Interindividual variability (CV [%]) | ||||
| CL/F | 36 | 39 | 34 | 16–49 |
| CLD-P2/F | 86 | 48 | 86 | 3–133 |
| Vc/F | 114 | 29 | 116 | 75–161 |
| VP1/F | 60 | 48 | 60 | 0.5–110 |
| Residual error (CV [%]) | 32 | 34 | 32 | 18–42 |
a
Abbreviations: RSE, relative standard error; CV, coefficient of variation; ka, absorption rate constant; tlag, lag time; CL/F, oral clearance; CLD-P1/F, apparent intercompartmental clearance from the central compartment to peripheral compartment 1; CLD-P2/F, apparent intercompartmental clearance from the central compartment to peripheral compartment 2; Vc/F, apparent volume of the central compartment; VP1/F, apparent volume of peripheral compartment 1; VP2/F, apparent volume of peripheral compartment 2.