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. 2012 Feb;56(2):830–837. doi: 10.1128/AAC.05438-11

Table 1.

IC50s of filibuvir, VX-222, and ANA-598 for RNA synthesis by 1bΔ21 from five different templates

Template Mean IC50 in μM (n)a
Filibuvir VX-222 ANA-598 HCV-796
Poly(rA)-oligo(dT)18 0.05 ± 0.027 (6) 0.011 ± 0.005 (4) 0.005 ± 0.004 (4)
Poly(I/C) 0.4 (2) 0.016 (1) 0.003 (1)
cIRES >10 (2) 0.15 (2) 0.006 (2)
PE46 0.073 ± 0.051 (4) 0.031 ± 0.011 (4) 0.005 (2) 0.013 (1)
LE19P >50 (4) >5 (4) 0.004 (2) 0.010 (1)
a

For some templates, the standard error of the mean is also provided. n is the number of data sets.