Table 1.
Pharmacokinetics and pharmacodynamics of daptomycin and vancomycin
| Antimicrobial | No. of xxxd | Dose (mg/kg) | Cmax (mg/liter) | AUC0–∞ (mg · h/liter) | t1/2 (h) | AUC0-24/MIC ratio |
|---|---|---|---|---|---|---|
| Daptomycin | 42 | 50 | 162.21 | 595.39 | 1.91 | 595.39a |
| Vancomycin | 42 | 110 | 97.79 | 111.36 | 0.57 | 111.36b |
| 222.72c |
a
Parameter calculated for both strains using MICs of daptomycin of 1 mg/liter and a daptomycin dose of 50 mg/kg/day.
b
Parameter calculated for strain SE284 using MICs of vancomycin of 4 mg/liter and a vancomycin dose of 440 mg/kg/day.
c
Parameter calculated for strain SE385 using MICs of vancomycin of 2 mg/liter and a vancomycin dose of 440 mg/kg/day.
d
Three mice every time point.