Table 2.

MICs of β-lactam antibiotics for the K. pneumoniae clinical strain producing the SHV-107 enzyme, recipient, and transformant^a

Antimicrobial drug	MIC (μg/ml) for strain:
	K. pneumoniae INSRA6884 (SHV-107 + GES-7)	E. coli BL21(DE3)	E. coli BL21(DE3)(pBK-SHV-107)	E. coli C600	E. coli C600 (GES-7)
Amoxicillin	2,048	≤2	256	≤2	256
Amoxicillin + CLAb	512	≤2	64	≤2	8
Ticarcillin	>2,048	≤2	128	≤2	2,048
Piperacillin	64	1	8	0.5	4
Piperacillin + TAZc	4	1	1	0.5	0.5
Amdinocillin	1	≤0.015	≤0.015	≤0.015	0.25
Cephalothin	128	1	1	4	32
Cefuroxime	64	0.5	1	2	16
Cefoperazone	8	≤0.25	≤0.25	≤0.25	0.5
Ceftazidime	128	0.06	0.06	0.06	32
Ceftazidime + CLA	8	0.03	0.03	≤0.015	0.5
Ceftriaxone	4	≤0.015	≤0.015	≤0.015	0.5
Ceftriaxone + CLA	0.5	≤0.015	≤0.015	≤0.015	≤0.015
Cefotaxime	4	≤0.015	≤0.015	0.03	0.5
Cefotaxime + CLA	0.25	≤0.015	≤0.015	≤0.015	0.03
Aztreonam	2	≤0.015	≤0.015	0.06	1
Aztreonam + CLA	0.125	≤0.015	≤0.015	0.03	0.03
Cefepime	0.25	≤0.015	≤0.015	≤0.015	0.06
Cefoxitin	4	2	2	2	2
Imipenem	0.25	0.25	0.25	≤0.06	≤0.06
Kanamycin	4	≤0.125	≤0.125	≤0.125	≤0.125
Nalidixic acid	4	≤0.003	≤0.003	4	4
Ciprofloxacin	0.03	≤0.003	≤0.003	0.007	0.007
Trimethoprim	0.5	≤0.125	≤0.125	≤0.125	≤0.125

^aE. coli BL21(DE3)(pBK-SHV-107) and E. coli C600 (GES-7) were a transformant and conjugant, respectively, of K. pneumoniae INSRA6884 (harboring SHV-107 plus GES-7 enzyme).

^bCLA, clavulanate at a fixed concentration of 2 μg/ml.

^cTAZ, tazobactam at a fixed concentration of 4 μg/ml.