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Clavulanate kinetic parameters of SHV-1 and SHV-107 β-lactamases
| β-Lactamase | Ki (μM)a | kinact (s−1)a | kinact/Ki (μM−1 · s−1) | kcat (s−1)a | kcat/Ki (μM−1 · s−1) | kcat/kinact |
|---|---|---|---|---|---|---|
| SHV-1 | 0.21 ± 0.06 | 0.050 ± 0.007 | 0.23 | 0.94 ± 0.13 | 4.48 | 19 |
| SHV-107 | 1.82 ± 0.17 | 0.042 ± 0.009 | 0.02 | 0.75 ± 0.11 | 0.41 | 18 |
Values are means ± standard deviations.
