Fig 1.
Population pharmacokinetic model for the simultaneous prediction of lamivudine concentrations in the mother, cord, and amniotic fluid. A two-compartment model with first-order absorption and elimination best described maternal data. For concentrations in cord blood, an effect compartment is linked to the maternal plasma compartment by a first-order process. Amniotic fluid concentrations were linked to the fetal compartment via the fetal swallowing flow and fetal elimination rate constant. ka denotes the absorption rate constant, CL denotes the maternal elimination clearance from the central compartment, Vc denotes the volume of the central maternal compartment, Q denotes the maternal intercompartmental clearance, Vp denotes the volume of the peripheral maternal compartment, kMF denotes maternal-to-fetal rate constant, kFM denotes the fetal-to-maternal rate constant, and keF denotes the fetal elimination rate constant.