Table 1.
Genotype characteristics and MIC ranges of eight antimicrobial agents against 40 M. pneumoniae clinical isolates
| Sequence type of p1 gene | Mutation in 23S rRNA gene | No. of isolates | MICa (μg/ml) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ERY | CLR | AZM | JOS | TET | CIP | LVX | GAT | |||
| Type I | A2063G | 37 | 256–>256 | 64–>256 | 8–64 | 2–8 | 0.032–0.125 | 0.5–2 | 0.25–2 | 0.032–0.125 |
| Type I | A2064G | 1 | >256 | >256 | 32 | 4 | 0.125 | 1 | 1 | 0.125 |
| Type I | None | 2 | 0.008–0.016 | <0.008 | <0.008 | 0.064 | 0.125 | 0.5–1 | 1 | 0.125 |
a
MICs were determined by microdilution methods using SP4 broth. The MIC of each agent was defined as the lowest concentration of each antibiotic preventing the color change. ERY, erythromycin; CLR, clarithromycin; AZM, azithromycin; JOS, josamycin; TET, tetracycline; CIP, ciprofloxacin; LVX, levofloxacin; GAT, gatifloxacin.