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Simulated AUC and Cmin values for pregnant women following daily administration of 136 or 272 mg of TFV (which corresponds to 300 and 600 mg of TDF) compared to values for nonpregnant women
| Parameter | Mean (95% CI) |
||
|---|---|---|---|
| Nonpregnant women (one tablet, 136 mg) | Pregnant women |
||
| One tablet (136 mg) | Two tablets (272 mg) | ||
| AUC (mg/liter · h) | 2.4 (1.1–5.2) | 1.6 (0.9–3.3) | 3.4 (1.7–6.5) |
| Cmin (mg/liter) | 0.061 (0.031–0.164) | 0.039 (0.022–0.092) | 0.078 (0.049–0.175) |
