Table 3.
Comparison and correlation of sulfamethoxazole AUC0-24 and clinical characteristics
| Characteristic | Mean AUC0-24 (μg-h/ml) ± SD | Correlation coefficient (r) | P value |
|---|---|---|---|
| Sex | 0.9464 | ||
| Male | 574.4 ± 314.4 | ||
| Female | 578.5 ± 330.4 | ||
| CYP2C9 genotype group | 0.7019 | ||
| *1/*1 | 579.2 ± 323.1 | ||
| *1/*3 | 534.1 ± 287.0 | ||
| NAT2 genotype group | 0.0431 | ||
| RA | 537.2 ± 257.5 | 1.0000 (RA vs IA) | |
| IA | 561.8 ± 332.1 | 0.0901 (IA vs SA) | |
| SA | 766.4 ± 432.3 | 0.0430 (RA vs SA) | |
| Age | 0.0626 | 0.5003 | |
| Body wt | 0.0423 | 0.6489 | |
| Aspartate transaminase | −0.1407 | 0.1286 | |
| Alanine transaminase | −0.1183 | 0.2020 | |
| Serum albumin | −0.0602 | 0.5172 | |
| Total bilirubin | 0.0317 | 0.7334 | |
| Serum creatinine | 0.0853 | 0.3561 | |
| Creatinine clearance | −0.1667 | 0.0712 | |
| Platelet | −0.0671 | 0.4705 |