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Relationship between VKORC1 variants 1 and 2. Sequences and diagrammatic representations of the predicted structures of VKORC1 variants 1 and 2 are shown. The membrane topology shown for VKORC1v1 corresponds to that deduced by Tie et al. (21). Variant 2 shares the first 58 amino acids with variant 1; residues 59 to 92 are unique.
