Table 3.

Outcome indices for patients treated with scopolamine (n=22).

	Baseline Block	Block 1	Block 2
S/P group (n=11)
Full Response (> 50%)	0	4	5
Partial Response (25–49%)	2	3	1
Non-response (< 25%)	9	4	5
P/S group (n=11)
Full Response	0	1	9
Partial Response	0	3	1
Non-response	11	7	1

Each entry reflects the number of participants from the identified group showing the described effect. When the two groups were combined, by study end 14 of the 22 (64%) subjects achieved a full response (11 of whom experienced remission based upon attaining a MADRS score≤10). Of these, one subject attained full response and remission under placebo, and this response persisted during the subsequent scopolamine sessions. The remaining subjects achieved full response and/or remission under scopolamine.

Abbreviations: P/S – subjects randomized to receive placebo in study block 1 and scopolamine in block 2; S/P – subjects randomized to receive scopolamine in block 1 and placebo in block 2