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. 2012 Jan 23;7(1):e30139. doi: 10.1371/journal.pone.0030139

Figure 7. Effectors generated with CD40-B cell immunization contract more rapidly than the one obtained with DC immunization.

Figure 7

A. Contraction of the OVA-specific CD8+ T cell response. Mice were immunized as described in Figure 2. Lymph nodes were surgically removed at 4, 7, 10 and >30 days post-immunization. Cells were stained to determine the percentage of Te cells generated. The graph shows the percentage of remaining Te cells (CD8+CD45.2+) over time relative to the peak of the response (d4). B. Effectors generated with CD40-B cell and DC immunization express similar amount of Bcl-2 during the course of the CD8+ T cell response. The MFI of Bcl-2 for OVA-specific CD8+ Te cells was normalized to the MFI of endogenous CD8+ T cells to obtain a MFI ratio. 3 independent experiments. * p<0.05, ** p<0.01 and *** p<0.001.