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. 2012 Jan 23;7(1):e30339. doi: 10.1371/journal.pone.0030339

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Yan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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All mutations by pyro-sequencing analysis were located at codon 132. And 89.5% of them were G395A transition (Arg→His), followed by C394A transversion (Arg→Ser; 10.5%) (A). Kaplan-Meier Survival Analysis showed that pGBM patients carrying an IDH1 mutation (dotted line) had significantly longer progression free survival (p = 0.026; log-rank test) and overall survival (p = 0.029; log-rank test) (B).