Table 2. Effects on some lipid parameters of SUB885C and existing drugs in the ApoE^*3Leiden.CETP female mice model.

	SUB885C	Rimonabant [34]	Atorvastatin [15]	Torcetrapib [14]	Niacin [44]	Tesaglitazer [17]
Mice age	6–10 wk	6–10 wk			12 wk	18 wk
Run-in diet	4 wk	4 wk	2 wk	4 wk	3 wk	11 wk: 0.3% w/w
(cholesterol)	0.2% w/w	0.2% w/w	0.1% w/w	0.25% w/w	0.1% w/w	4 wk: 0.1%w/w
Study diet	same as run-in diet	same as run-in diet	same as run-in diet	same as run-in diet	same as run-in diet	0.1% w/w
(cholesterol)
Study period	4 wk	4 wk	6 wk	14 wk	3 wk	8 wk
TC	−49%	−24%	−33%	−20%	−44–68%*	−55%
TG	−41% (NS)	−43% (NS)	NS		−57–77%*	−71%
HDL-C	+39%	+12% (NS)	+52%	+30%	+77–87%*	+38%
(V)LDL-C	−7%	−33%	−88%	−26%	−52–79%*	−80%
CETP level	−31%	−4% (NS)	−29% (NS)	+33%	−24–45%*	−42%
CETP activity	−74%	−22% (NS)	−36%	−73%	−24–52%*	−56%

Basic diet for ApoE*3Leiden.CETP female mice during run-in and study period: Western type diet with 15% w/w fat plus different content of cholesterol.

NS: no significance.

*Dependent on different doses of Niacin.