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. 2012 Jan 23;7(1):e30699. doi: 10.1371/journal.pone.0030699

Figure 1. Behavioral nociceptive responses and temporal changes in VB neuronal firing patterns induced by formalin in behaving mice.

Figure 1

(A) Behavioral pain responses to formalin analyzed in 5 min segments (F = 14.42, p<0.01). All data points are mean±SEM. n = 9 mice. ANOVA with Repeated measures were used for statistical analysis over time. (B) Spike sorting sample from a tetrode. (C) Normalized overall VB neuronal firing rate changes to formalin over time in 5 min segments. (D) Normalized tonic firing and burst firing rate changes to formalin over time in 5 min segments. (C and D) n = 48 neurons, 7 mice. All data points are mean±SEM. Dotted line is the behavioral nociceptive responses superimposed for comparison with the VB neuronal firing responses. Student's t-test was used to compare each data points with the baseline. *indicates significant differences at p<0.05.