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. 2012 Jan 23;7(1):e30980. doi: 10.1371/journal.pone.0030980

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Liu, Xue.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The gsb-res transgene corresponds to the enlarged 20-kb genomic fragment in Fig. 1A , which includes the gsb transcribed region as well as adjacent 14-kb upstream and 3-kb downstream sequences [9]. The upstream sequence also contains the 5′ portion of the gsbn up to part of the third exon. In gsb-Prd and gsb-Pax3 transgenes, the gsb coding region (except of a small region encoding the C-terminus) is replaced by prd and Pax3 cDNAs, while upstream and downstream regions are retained. The gsb intron is also retained by inserting it between sequences of the gsb and prd or Pax3 leaders. Coding regions are indicated as black boxes except for the paired-domain (PD) and the prd-type homeodomain (HD) which are hatched. The gsb and gsbn introns are indicated as open boxes. The transcription start of gsb is marked by 0, and poly(A) addition signals AATAAA are indicated.