Figure 5.

Change (Δ) in 24 hr mean arterial pressures (MAP) across pregnancy in BALB/c +/+ (○; n=5) and Rag2 ^−/−/Il2rg^−/− (●; n=9) for females delivering live born offspring. Because no changes from a 4 day pre-conception baseline were found during pre-implantation gestation in these mice or C57Bl/6J, gd0–3 mean 24 hr MAP was used for subsequent daily 24hr mean statistical comparisons³¹. Both strains showed a decline in ΔMAP shortly after implantation that continued until the time of spiral arterial modification and opening of the placental circulation (~gd9–10). The decline was statistically significant from the pre-implantation baseline for Rag2 ^−/−/Il2rg^−/−. A gain in ΔMAP followed and baseline values were achieved a few days later. These remained relatively stable, without hypertension until parturition (P). A pattern of late gestational hypertensive (not shown) was seen in two Rag2 ^−/−/Il2rg^−/− females that gave birth to litters of stillborn pups³¹.