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. Author manuscript; available in PMC: 2013 Jan 18.

Published in final edited form as: J Am Chem Soc. 2011 Dec 29;134(2):999–1009. doi: 10.1021/ja207173p

Electron density maps of the FAD and NAD(H) binding sites in (a) ligand-free XDH, (b) ligand-free XO, (c) the XDH-NADH complex, and (d) the XDH-NAD⁺ complex. For clarity, only the FAD, NAD(H), and Asp429 are shown in atom representation. The backbone trace of the 423-433 loop is indicated by a green thread. Although the loop seems to swing away from the flavin ring in XO it does interfere with dinucleotide access in its new location.

Electron density maps of the FAD and NAD(H) binding sites in (a) ligand-free XDH, (b) ligand-free XO, (c) the XDH-NADH complex, and (d) the XDH-NAD⁺ complex. For clarity, only the FAD, NAD(H), and Asp429 are shown in atom representation. The backbone trace of the 423-433 loop is indicated by a green thread. Although the loop seems to swing away from the flavin ring in XO it does interfere with dinucleotide access in its new location.