Table 2.
Rate and Hazard Ratios of Treated Diabetes in Patients Exposed to Second-Generation Antipsychoticsa, By Doseb and Drug
| Dose category | Patients exposed (N) | Events (N) | Person-years | Diabetes rate (per 100 person-years) |
Adjustedc HRd (95% CIe) |
|---|---|---|---|---|---|
| Aripiprazole | pf = 0.43 | ||||
| ≥15 mg | 1321 | 4 | 371 | 1.1 | 1.3 (0.1, 12.2) |
| 10 - <15 mg | 988 | 1 | 214 | 0.5 | 0.6 (0.04, 9.8) |
| <10 mg | 788 | 1 | 145 | 0.7 | Reference |
| Olanzapine | pf = 0.002 | ||||
| ≥10 mg | 5921 | 58 | 2176 | 2.7 | 2.5 (1.4, 4.5) |
| 5 - <10 mg | 6761 | 41 | 2118 | 1.9 | 1.7 (1.0, 3.1) |
| <5 mg | 4398 | 15 | 1361 | 1.1 | Reference |
| Quetiapine | pf = 0.007 | ||||
| >150 mg | 4686 | 34 | 1686 | 2.0 | 2.5 (1.3, 4.7) |
| 51 -150 mg | 5525 | 15 | 1610 | 0.9 | 1.2 (0.6, 2.5) |
| ≤50 mg | 6516 | 13 | 1838 | 0.7 | Reference |
| Risperidone | pf = 0.10 | ||||
| ≥ 2 mg | 5103 | 23 | 1852 | 1.2 | 2.1 (1.0, 4.4) |
| 1 - <2 mg | 5187 | 15 | 1649 | 0.9 | 1.4 (0.6, 3.1) |
| <1 mg | 4353 | 10 | 1372 | 0.7 | Reference |
| Ziprasidone | pf = 0.60 | ||||
| >80 mg | 624 | 1 | 186 | 0.5 | 0.3 (0.03, 3.4) |
| 41 - 80 mg | 671 | 2 | 170 | 1.2 | 0.6 (0.1, 4.0) |
| ≤40 mg | 725 | 3 | 181 | 1.7 | Reference |
aResults from clozapine not included because numbers were insufficient.
bDose per day
cAdjusted for age, sex, study site, year of cohort entry, history of antipsychotic use (>3 months prior to index), exposure to other pharmacotherapy (alpha blockers, beta blockers, statins, corticosteroids, fibrates, lithium, oral contraceptives, thiazide (and related) diuretics, valproate, hydantoin), and obesity
dHR = hazard ratio
eCI = confidence interval
f test for trend