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. Author manuscript; available in PMC: 2013 Jan 20.
Published in final edited form as: Cell. 2012 Jan 5;148(1-2):285–295. doi: 10.1016/j.cell.2011.12.007

Figure 5.

Figure 5

Summary of chimera studies with monkey embryos and embryonic cells.

Rhesus monkey ESCs as well as isolated ICMs, blastomeres or whole embryos were tested for their ability to incorporate into host embryos and generate chimeric offspring. Established ESCs and freshly isolated ICMs failed to produce chimeras when injected into host blastocysts. However, ICMs developed into separate fetuses with placental support from the host embryo. Aggregating of several 4-cell embryos efficiently produced live chimeric offspring. (See also Figure S7 and Movie S1)