Table 1.
Tested cells | Host embryo stage | Total offspring generated | Developed to separate embryo | Developed to embryo proper chimera |
---|---|---|---|---|
ORMES-22 | Blastocyst | 4 | No | No |
ORMES-23 | Blastocyst | 2 | No | No |
CRES-2 GFP | Blastocyst | 1 | No | No |
Whole ICM | Blastocyst | 3 | Yes | Restricteda (hematopoietic) |
4-cell embryo | 4-cell embryo | 10 | No | Yes |
ORMES-22 GFP | 4-cell embryo | 1 | No | No |
Chimerism was restricted to livers, spleens and placentas.
ORMES-22 (XX) and -23 (XY) are IVF-derived rhesus monkey embryonic stem cell lines. CRES-2 (XY) is SCNT-derived ESC line(Byrne et al., 2007)
(See also Tables S1 through S6, Figures S1 through S6, and Movie S1)