Table 2.
Time Window |
Brain Region |
Emotional Valence |
ERO energy differences between participant groups by emotional stimuli1 |
ERO energy differences across emotional stimuli by participant group2 |
Heritability | Linkage Findings | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
ASPD/CD | Controls | h2 | p | Chr | Position (cM) |
LOD score |
p | ||||
0–250 ms | F | H | No difference | 0.32 | <0.0001 | No LOD scores >2.00 | |||||
N | No difference | H=N=S | H=N=S | 0.43 | <0.0001 | No LOD scores >2.00 | |||||
S | No difference | 0.33 | <0.0001 | No LOD scores >2.00 | |||||||
C-P | H | ASPD/CD>Controls | 0.46 | <0.0001 | 6 | 54 | 2.22 | 0.0025 | |||
N | ASPD/CD>Controls | 0.32 | <0.0001 | No LOD scores >2.00 | |||||||
S | ASPD/CD>Controls | H=N=S | H=N=S | 0.35 | <0.0001 | 2 | 128 | 2.24 | 0.0025 | ||
3 | 99 | 2.36 | 0.0020 | ||||||||
12 | 107 | 2.06 | 0.0036 | ||||||||
17 | 101 | 2.35 | 0.0021 | ||||||||
400–700 ms | F | H | No difference | 0.43 | <0.0001 | No LOD scores >2.00 | |||||
N | No difference | 0.41 | <0.0001 | 13 | 95 | 2.01 | 0.0101 | ||||
S | No difference | 0.44 | <0.0001 | 2 | 175 | 2.16 | 0.0031 | ||||
H=N=S | H=N=S | 4 | 61 | 2.33 | 0.0020 | ||||||
8 | 81 | 2.17 | 0.0030 | ||||||||
14 | 44 | 2.16 | 0.0031 | ||||||||
20 | 102 | 2.62 | 0.0012 | ||||||||
22 | 58 | 2.30 | 0.0022 | ||||||||
C-P | H | ASPD/CD>Controls | 0.34 | <0.0001 | 1 | 9 | 2.40 | 0.0009 | |||
N | ASPD/CD>Controls | H=N>S | H>N>S | 0.22 | <0.0001 | No LOD scores >2.00 | |||||
S | No difference | 0.29 | <0.0001 | 1 | 9 | 2.79 | 0.0021 | ||||
12 | 125 | 2.06 | 0.0036 |
The age and gender of the participant were assessed as potential covariates in the models. ASPD/CD = Antisocial Personality Disorder/Conduct Disorder. h2 = genetic heritability. F = Frontal and C-P = Centro-parietal. H = Happy faces, N = Neutral faces, and S = Sad faces. Controls = participants without ASPD or CD diagnosis. Chr = chromosome. cM = centimorgan. LOD = logarithm of the odds. Significant age differences in heritability were found in all models (p < 0.05). Significant gender differences in heritability were found in most models (p < 0.05), except in the frontal regions of the 0 – 250 ms time interval in response to all three emotional expressions. Bold text indicates evidence of linkage, p-value < 0.001, 1 - > symbol significant difference between participant groups (p<0.004), 2 - > symbol indicates significant difference between these categories of emotional stimuli (p<0.004 and post hoc (p<0.05)).