. Author manuscript; available in PMC: 2013 Feb 1.

Published in final edited form as: Brain Behav Immun. 2011 Sep 21;26(2):218–227. doi: 10.1016/j.bbi.2011.09.006

Table 1.

Impact of high-dose rate gamma irradiation on TNF-α, IL-1RA and Arc gene transcripts in cerebral hippocampus, hypothalamus, cortex, and cerebellum at 4, 8, 12 and 24 h post irradiation.

Brain region	Time post-irradiation	Restraint-10				Restraint-240
Brain region	Time post-irradiation	Gene	Sham IR	50 cGy	200 cGy	Sham IR	50 cGy	200 cGy
Hippocampus	4 h	TNF-α^*^#	1.000 (0.253)^a,c	1.144 (0.133)^a,c	1.535 (0.211)^a	0.394 (0.261)^b,c	0.599 (0.075)^c	1.326 (0.450)^a
Hippocampus	4 h	Arc^#	1.000 (0.132)^a	0.886 (0.098)^a	0.974 (0.147)^a	1.730 (0.172)^b	1.303 (0.184)^a,b	1.326 (0.177)^a,b
Hypothalamus	4 h	TNF-α^*^#	1.000 (0.320)^a	0.985 (0.260)^a,b	1.019 (0.180)^a	1.235 (0.355)^b,c	1.248 (0.127)^c	1.260 (0.339)^a
Hypothalamus	4 h	IL-1RA^#	1.000 (0.437)^a,b	0.668 (0.199)^a,b	1.313 (0.137)^a	0.630 (0.381)^a,b	0.560 (0.194)^b	0.683 (0.275)^a,b
Cortex	4 h	TNF-α^*^#^†	1.000 (0.237)^a	1.076 (0.137)^a	1.226 (0.184)^a	0.420 (0.220)^b	0.516 (0.110)^b	1.096 (0.356)^a
Cortex	4 h	Arc^*^#	1.000 (0.154)^a,b,c	0.573 (0.157)^a	0.667 (0.127)^a,c	1.732 (0.375)^b	1.426 (0.227)^b	1.199 (0.272)^b,c
Cerebellum	4 h	TNF-α^*^#	1.000 (0.121)^a	0.963 (0.131)^a	1.164 (0.198)^a	0.522 (0.146)^b	0.465 (0.233)^b	0.822 (0.352)^a,b
Cerebellum	4 h	Arc^#^§	1.000 (0.062)^a	0.923 (0.042)^a	0.895 (0.092)^a	0.532 (0.083)^c	0.573 (0.130)^b,c	0.786 (0.147)^a,b
Hippocampus	8 h	TNF-α^*	1.000 (0.127)^a	1.338 (0.094)^a	2.093 (0.136)^b	1.002 (0.146)^a	1.200 (0.131)^a	1.965 (0.138)^b
Hippocampus	8 h	IL-1RA^*	1.000 (0.491)^a,c	0.909 (0.204)^a	1.880 (0.203)^b,c	1.537 (0.249)^a,b,c	1.008 (0.203)^a,c	2.280 (0.103)^b
Hippocampus	8 h	Arc^#	1.000 (0.127)^a,b	0.972 (0.108)^a,b	1.124 (0.159)^a	0.904 (0.141)^a,b	0.782 (0.094)^b	0.869 (0.106)^a,b
Hypothalamus	8 h	Arc^#^†	1.000 (0.088)^a	1.066 (0.087)^a	0.770 (0.194)^a,b	0.610 (0.111)^b,c	0.473 (0.205)^c	0.674 (0.118)^b,c
Cortex	8 h	TNF-α^*	1.000 (0.224)^a,b	1.092 (0.094)^a,b	1.645 (0.264)^a	0.732 (0.140)^b	1.395 (0.336)^a	1.454 (0.212)^a
Cortex	8 h	IL-1RA^*^§	1.000 (0.159)^a	1.109 (0.067)^a	3.043 (0.196)^b	1.199 (0.183)^a	1.188 (0.157)^a,b	2.630 (0.085)^b
Hippocampus	12 h	TNF-α^*^†	1.000 (0.176)^a	1.497 (0.146)^b,c	1.890 (0.136)^c	1.123 (0.123)^a,b	1.173 (0.111)^a,b	2.409 (0.152)^c,d
Hippocampus	12 h	IL-1RA^*	1.000 (0.261)^a	1.873 (0.241)^b	2.391 (0.210)^b	1.731 (0.167)^a,b	1.692 (0.275)^a,b	2.991 (0.123)^b
Cortex	12 h	TNF-α^*^#	1.000 (0.191)^a	1.131 (0.172)^a,b	1.732 (0.149)^b	1.131 (0.202)^a,b	1.154 (0.165)^a,b	2.899 (0.205)^c
Cortex	12 h	IL-1RA^*^†^§	1.000 (0.076)^a	1.157 (0.055)^a	2.454 (0.067)^b	1.374 (0.113)^a	1.228 (0.117)^a	3.499 (0.113)^b
Hippocampus	24 h	TNF-α^*	1.000 (0.110)^a	1.109 (0.071)^a,b	1.529 (0.158)^b,c	1.050 (0.070)^a,b	1.166 (0.263)^a,b	1.807 (0.147)^c
Hippocampus	24 h	IL-1RA^*	1.000 (0.218)^a,b	0.804 (0.306)^a	1.133 (0.159)^a,b	0.894 (0.175)^a,b	1.049 (0.337)^a,b	1.524 (0.097)^b
Cortex	24 h	TNF-α^*	1.000 (0.227)^a	1.108 (0.100)^a,c	1.803 (0.154)^b,c	1.073 (0.146)^a	1.139 (0.254)^a,c	2.332 (0.184)^b
Cortex	24 h	IL-1RA^*^†	1.000 (0.215)^a,b	0.662 (0.169)^a	1.054 (0.141)^a,b	0.697 (0.164)^a	0.855 (0.304)^a	1.580 (0.123)^b
Cortex	24 h	Arc^*^†	1.000 (0.191)^a	0.648 (0.123)^a,b,c	0.431 (0.060)^c	0.564 (0.126)^b,c	0.678 (0.170)^a,b	0.747 (0.258)^a,b

Results are expressed as relative fold change in mRNA expression (ΔmRNA), means (s.e.m.); n = 6.

P < 0.05, significant main effect of dose.

P < 0.05, significant main effect of restraint-240.

^†

P < 0.05, significant dose-restraint-240 interaction. Results within individual rows without a common superscript letter are different (P < 0.05).

^§

indicates data was transformed using ((Original value)²)^1/4).