TABLE 1.
Baseline Characteristics of 981 Participants by Quartile of Adiponectin.
| Quartile of adiponectin |
|||||
|---|---|---|---|---|---|
| I | II | III | IV | ||
| Adiponectin level (µg/mL) | 1.2 – 12.6 | 12.6 – 21.3 | 21.3 – 35.6 | 35.6 – 121 | |
| N in each quartile | 246 | 245 | 245 | 245 | P value |
| Demographic characteristics | |||||
| Age (yr) | 64.0±10.5 | 64.9±10.2 | 67.6±10.9 | 70.5±11.2 | <.0001 |
| Male sex | 219(89%) | 203(83%) | 192(78%) | 186(76%) | 0.001 |
| White race | 125(51%) | 133(54%) | 155(63%) | 178(73%) | <.0001 |
| Current smoking | 49(20%) | 55(23%) | 46(19%) | 43(18%) | 0.52 |
| Medical history | |||||
| Hypertension | 185(75%) | 164(67%) | 175(72%) | 167(68%) | 0.21 |
| Myocardial infarction | 141(58%) | 126(52%) | 127(52%) | 131(53%) | 0.55 |
| Congestive heart failure | 41(17%) | 44(18%) | 42(17%) | 46(19%) | 0.92 |
| Diabetes mellitus | 88(36%) | 71(29%) | 51(21%) | 49(20%) | <.0001 |
| Current medication use | |||||
| Beta-blocker | 169(69%) | 135(55%) | 147(60%) | 112(46%) | <.0001 |
| Aspirin | 212(86%) | 183(75%) | 190(78%) | 174(71%) | 0.0005 |
| Statin | 178(72%) | 150(61%) | 155(63%) | 148(60%) | 0.02 |
| ACE inhibitor or ARB | 139(57%) | 117(48%) | 120(49%) | 129(53%) | 0.2 |
| Metabolic variables | |||||
| Body mass index (kg/m2) | 29.7±5.7 | 29.1±5.2 | 28.3±5.3 | 26.6±4.7 | <.0001 |
| HDL cholesterol (mg/dL) | 39.2±10.2 | 42.5±10.9 | 46.7±12.5 | 54.3±16.8 | <.0001 |
| Non-HDL cholesterol (mg/dL) | 132.4±36.1 | 142.5±49.1 | 129.7±40.2 | 123.2±37.4 | <.0001 |
| Triglycerides (mg/dL) | 179.9±177.8 | 160.5±144.1 | 118.5±69.1 | 105.2±77.6 | <.0001 |
| Serum insulin (pg/mL) | 466.4±502.5 | 397.0±662.9 | 358.4±313.3 | 289.3±247.2 | 0.0003 |
| Fasting glucose (mg/dL) | 127.5±40.0 | 121.2±45.3 | 116.8±38.3 | 114.5±47.1 | 0.004 |
| Glycosylated hemoglobin (%) | 6.1±1.2 | 6.0±1.3 | 5.9±1.1 | 5.9±1.1 | 0.07 |
| eGFR | 79±22 | 79±23 | 75±25 | 71±22 | <.0001 |
| Cardiac function | |||||
| LV ejection fraction (%) | 61.9±9.6 | 62.7±8.3 | 62.2±9.6 | 60.2±10.7 | 0.03 |
| Diastolic dysfunction | 20(9%) | 16(7%) | 28(13%) | 42(20%) | 0.0004 |
| Inducible ischemia | 43(18%) | 52(23%) | 48(22%) | 74(33%) | 0.002 |
| Log C-reactive protein | 0.8±1.3 | 0.6±1.3 | 0.8±1.3 | 0.6±1.4 | 0.08 |
| Log NT-proBNP | 4.8±1.3 | 5.0±1.2 | 5.3±1.3 | 5.9±1.3 | <.0001 |
Values are expressed as mean +/− standard deviation or number ( % within quartile ).
Abbreviations: ACE: angiotensin converting enzyme; ARB: angiotensin receptor blocker; HDL: high-density lipoprotein; eGFR: estimated glomerular filtration rate; LV: left ventricular; NT-proBNP: amino terminal fragment of the prohormone of brain-type natriuretic peptide.