Skip to main content
. Author manuscript; available in PMC: 2013 Feb 3.
Published in final edited form as: Brain Res. 2011 Dec 14;1436:81–91. doi: 10.1016/j.brainres.2011.12.013

Figure 3.

Figure 3

Estradiol directly modulates AM sodium currents in GnRH neurons from time-reversed animals. (A) Mean AM current density in estradiol-treated neurons (dark) is significantly reduced when compared to control (white; *, p = 0.006) or PM currents (p = 0.03; n = 20–25). (B) Delaying the time of sacrifice and dissociation for three hours (black) does not shift the overall curve, and AM currents are significantly smaller than PM currents (p = 0.003, 1500–1600 h vs 1000–1200 h, n = 8–19). The typical dissociation curve (white; from Figure 2) is provided for comparison.