. Author manuscript; available in PMC: 2013 Mar 5.

Published in final edited form as: Mol Cell Endocrinol. 2011 Dec 8;350(1):72–77. doi: 10.1016/j.mce.2011.11.022

Table 4.

Linear regression model of prolactin level in women with PCOS including COMT haplotype specified according to reported enzymatic activity.

Term	Estimate (S.E.)	P-value
COMT haplotypes	−0.525 (0.140)	0.0002
Age (years)	−0.065 0(0.029)	0.028
BMI (kg/m²)	−0.037 (0.020)	0.063
Total testosterone (ng/dl)	−0.007 (0.007)	0.314
Non-SHBG bound T (ng/dl)	0.018 (0.015)	0.253
Intercept	14.066 (1.201)	<0.0001

COMT haplotype SNP order: rs6269, rs4633, rs4818, rs4680. Ordered COMT haplotypes: 1=ACCG/ACCG, 2=ACCG/ATCA, 3= ACCG/GCGG, 4= ATCA/ATCA, 5=ATCA/GCGG, 6=GCGG/GCGG. Haplotypes were ordered from 1 (low activity) to 6 (high activity) in accordance with reported information on enzyme activity (9). Haplotypes showed decreasing prolactin level as haplotypes moved from low to high activity alleles. S.E., standard error; BMI, body mass index.