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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Pain. 2011 Dec 1;153(2):410–419. doi: 10.1016/j.pain.2011.10.042

Figure 2. Phenotypes of C-fibers before and after injection of CFA into the hairy hindpaw skin as characterized by ex vivo recording.

Figure 2

A Most of the C-fibers are polymodal (CPMs) under normal conditions. The remaining C-fibers are approximately of equal representation comprised of those that respond to mechanical and cold stimulation (CMC), only mechanically sensitive (CM), mechanically insensitive but cold/cooling sensitive (CC) and mechanically insensitive but heat sensitive (CH). B, C, D: Inflamed C-fibers display no shift in the distribution of fiber types three days after CFA injection under any experimental condition. E: However, at five days post CFA, there is a significant increase (Naïve= 5%; CFA= 30%) in the percentage of mechanically insensitive C-fibers that respond to heat (CH). F: These findings are also observed after injection of control, non-targeting (PenCON) siRNAs (27%) and CFA at five days. G: The CFA induced recruitment of CH neurons at five days is unaffected by injection of P2Y1 targeting (PenY1) siRNAs (20%). p value < 0.01.