Table 3.
Inflammatory Cell Outcomes |
Non-Inflammatory Cell Outcomes |
||||||||
---|---|---|---|---|---|---|---|---|---|
Time | Group | Lymphocyte | Plasma Cells |
Macrophage | Giant Cells |
PMNs | Vascularity | Fibroblast | Cellularity |
7 days | Body wall xenograft |
0.83 (0–1) | 0.67 (0–1) | 1.5 (1–2) | 0.33 (0–1) | 1.17 (0–3) | 0.5 (0–1) | 1.17 (1–2) | 1 |
Shoulder xenograft |
1 | 1.25 (1–2) | 2 (1–3) | 0.5 (0–1) | 2 (1–3) | 0.5 (0–1) | 1.25 (1–2) | 1.17 (1–2) | |
28 days | Body wall xenograft |
1.8 (1–3) | 1.8 (1–2) | 2.7 (2–3) | 1.8 (1–3) | 0.4 (0–4) | 1.1 (1–2) | 1.6 (1–2) | 2.55 (1–4) |
Shoulder xenograft |
1.8 (1–3) | 1.3 (1–2) | 2.55 (2–3) | 1.35 (1–2) | 0.4 (0–4) | 1.1 (1–2) | 2.05 (1–3) | 3.15 (2–4) |
Histologic scoring was adapted from ISO 10993-6 standard.24 Inflammatory cell outcomes and vascularity: 1 = 1–5/hpf; 2 = 5–10/hpf; 3 = heavy infiltrate; 4 = packed. Fibroblasts: 1 = rare-100/hpf; 2 = 100–1,000/hpf; 3 = heavy infiltrate; 4 = packed. Cellularity: 1 ≤ 25%; 2 = 26-50%; 3 = 51-75%; 4 = >75%. hpf = high powered field (40×).