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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: J Orthop Res. 2011 Aug 19;30(3):461–467. doi: 10.1002/jor.21529

Table 3.

Histologic Scores; Mean (Range), n = 6

Inflammatory Cell Outcomes
Non-Inflammatory Cell Outcomes
Time Group Lymphocyte Plasma
Cells
Macrophage Giant
Cells
PMNs Vascularity Fibroblast Cellularity
7 days Body wall
 xenograft
0.83 (0–1) 0.67 (0–1) 1.5 (1–2) 0.33 (0–1) 1.17 (0–3) 0.5 (0–1) 1.17 (1–2) 1
Shoulder
 xenograft
1 1.25 (1–2) 2 (1–3) 0.5 (0–1) 2 (1–3) 0.5 (0–1) 1.25 (1–2) 1.17 (1–2)
28 days Body wall
 xenograft
1.8 (1–3) 1.8 (1–2) 2.7 (2–3) 1.8 (1–3) 0.4 (0–4) 1.1 (1–2) 1.6 (1–2) 2.55 (1–4)
Shoulder
 xenograft
1.8 (1–3) 1.3 (1–2) 2.55 (2–3) 1.35 (1–2) 0.4 (0–4) 1.1 (1–2) 2.05 (1–3) 3.15 (2–4)

Histologic scoring was adapted from ISO 10993-6 standard.24 Inflammatory cell outcomes and vascularity: 1 = 1–5/hpf; 2 = 5–10/hpf; 3 = heavy infiltrate; 4 = packed. Fibroblasts: 1 = rare-100/hpf; 2 = 100–1,000/hpf; 3 = heavy infiltrate; 4 = packed. Cellularity: 1 ≤ 25%; 2 = 26-50%; 3 = 51-75%; 4 = >75%. hpf = high powered field (40×).