Table 2.
Univariable and multivariable analysis of prognostic factors for BCR in a PSM cohort
| Variable | Univariable analysis HR (95% CI) | Multivariable analysis HR (95% CI) | P-value | Multivariable analysis HR (95% CI) | P-value |
|---|---|---|---|---|---|
| Age at RP | 1.00 (0.97–1.03) | N/A | N/A | N/A | N/A |
| PSA at diagnosis (ng/ml) | 1.04 (1.02–1.05) | 1.03 (1.01–1.05) | P = 0.002 | 1.04 (1.02–1.06) | P = 0.000 |
| Pathological stage (pT3 vs. pT2) | 2.36 (1.47–3.79) | 1.45 (0.82–2.58) | P > 0.05 | 1.42 (0.77–2.63) | P > 0.05 |
| RP Gleason score (per point) | 1.42 (1.15–1.76) | 1.34 (1.07–1.68) | P = 0.01 | 1.32 (1.04–1.66) | P = 0.02 |
| PNI | 2.20 (1.40–3.44) | 1.22 (0.71–2.09) | P > 0.05 | 1.43 (0.82–2.50) | P > 0.05 |
| Multiple vs. single PSM | 1.37 (0.72–2.64) | 1.05 (0.63–1.74) | P > 0.05 | N/A | N/A |
| Bilateral vs. unilateral PSM | 1.28 (0.79–2.07) | N/A | N/A | 1.32 (0.66-2.62) | P > 0.05 |
Values in italics are statistically signifiicant at P < 0.05
BCR biochemical recurrence, PSM positive surgical margin, HR hazard ratio, CI confidence interval, RP radical prostatectomy, PNI perineural invasion, N/A not applicable