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Immunohistochemistry of the kidney after DT administration. AQP7 localized in the S3 segment cells vanished from the kidney of a Tg mouse on day 3 after 75 μg/kg of DT administration (DT(+)), whereas a control mouse without DT administration (DT(−)) showed no abnormality. In the Tg mouse, megalin expressed in proximal tubule cells also partially disappeared. AQP2 in the collecting duct cells, THP in TAL cells, podocin in a glomerulus were not affected. Scale bars = 50 μm
