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BMSC treatment in T1DM-MCAO rats significantly increases BBB leakage, brain hemorrhage volume, and vascular density in the ischemic brain. A, Evans blue dye assay for BBB leakage (n=5/group). B–C, Brain hemorrhage (B) and vascular density (C) measurement. Scale bar in B and C=0.1 mm. BMSC indicates bone marrow stromal cell; T1DM, Type 1 diabetes mellitus; MCAO, middle cerebral artery occlusion; BBB, blood–brain barrier.
