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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Mol Cancer Res. 2012 Jan;10(1):143–155. doi: 10.1158/1541-7786.MCR-11-0208

Figure 8.

Figure 8

Ectopic expression of Msi1 partially recovers the effect of HuR silencing on apoptosis. (A) HuR or control siRNAs were transfected in U251:GFP and U251:MSI1 cells. (B) Similar experiments were performed in U343:GFP and U343:MSI1 cells. Apoptosis was measured 48 hours post-transfection using a luciferase-based reagent to monitor caspase-3/-7 activity. HuR silencing was able to induce apoptosis, while Msi1 ectopic expression partially inhibits this effect. Data was analyzed by the Student’s t-test and presented as the mean ± standard error of the mean. Experiment was performed in triplicate.