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. Author manuscript; available in PMC: 2012 Jun 22.
Published in final edited form as: N Engl J Med. 2011 Dec 10;365(25):2357–2365. doi: 10.1056/NEJMoa1108046

Figure 3. Cellular Immune Response in the Six Study Participants.

Figure 3

Results of the interferon-γ enzyme-linked immunosorbent spot assay for capsid-specific T-cell responses are shown as the maximum number of spot-forming units (SFU) per 1 million peripheral-blood mononuclear cells (PBMCs) in response to AAV8-capsid peptide pools. The horizontal lines in each panel represent the threshold for positivity, defined as three times the T-cell response for the negative control (medium only) and as at least 50 SFU per 1 million PBMCs. Liver-enzyme levels were elevated in Participant 5 at weeks 8 and 9 and in Participant 6 at week 9. In Participant 6, poor cell recovery and viability were noted at weeks 4 through 8.