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. 2012 Jan 18;2:103. doi: 10.3389/fgene.2011.00103

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Copyright © 2012 Reczko, Maragkakis, Alexiou, Papadopoulos and Hatzigeorgiou.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

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The precision and sensitivity of representative target prediction methods tested on the proteomics data. The tested programs are: Pictar, TargetScan 5.0, and DIANA-microT-ANN using the suggested three different score cutoffs denoted as strict (S), medium (M), and loose (L). Additionally the performance of a seed occurrence measure, detecting genes containing at least one occurrence of the miRNA seed is shown as a very sensitive prediction criterion, and the commonly used intersection of the predicted targets of Pictar, TargetScan 5.0, and miRBase as a very strict and precise measure. Three groups are highlighted indicating the methods with high sensitivity, medium, and high precision (from left to right).