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. Author manuscript; available in PMC: 2012 Jan 24.
Published in final edited form as: Curr Protoc Mol Biol. 2004 Nov;CHAPTER:Unit–19.4. doi: 10.1002/0471142727.mb1904s68

Table 19.4.1.

Web Addresses and Sizes of Selected Protein Databases

Database Web site Sizea
Sequence:
DDBJ http://www.ddbj.nig.ac.jp 138,030,308 entries
GeneCards http://bioinfo.weizmann.ac.il/cards/ 67,217 genes
InterPro http://www.ebi.ac.uk/interpro/ 14,633 families
NCBI http://www.ncbi.nlm.nih.gov NA
nr http://www.ncbi.nlm.nih.gov/BLAST/ NA
OWL http://www.bioinf.man.ac.uk/dbbrowser/OWL 279,796 entries
PIR http://pir.georgetown.edu NA
PRF http://www.genome.ad.jp/htbin/www_bfind?prf 1,365,912 entries
UniProt http://www.uniprot.org 531,473 proteins
SYSTERS http://systers.molgen.mpg.de NA
Structure:
3Dee http://www.compbio.dundee.ac.uk/3Dee/ NA
ArchDB http://sbi.imim.es/cgi-bin/archdb//loops.pl 41,294 classified loops
ASTRAL http://astral.berkeley.edu NA
BioMagResBank http://www.bmrb.wisc.edu 6339 entries
CDDB http://www.cdyn.org NA
EMDataBank http://EMDataBank.org 1138 EMDB maps
Enzyme Structures http://www.biochem.ucl.ac.uk/bsm/enzymes/ 10,208 structures
fPOP http://pocket.uchicago.edu/fpop/ >40,000 structures
JenaLib http://www.imb-jena.de/IMAGE.html NA
PMP http://www.proteinmodelportal.org 3,754,388 proteins
Proteopedia http://proteopedia.org >75,000 entries
MolMovDB http://bioinfo.mbb.yale.edu/MolMovDB/ NA
PDB http://www.pdb.org 75,594 structures
PDBLight http://mufold.org/pdblight.php 72,023 structures
PDBsum http://www.ebi.ac.uk/pdbsum/ 78,559 structures
PDBTM http://pdbtm.enzim.hu 1489 transmembrane structures
PDBWiki http://pdbwiki.org 74,296 structures
PISA http://pdbe.org/pisa NA
PMP http://www.proteinmodelportal.org 3,754,388 proteins
SBKB http://sbkb.org 5490 structures
TOPSAN http://www.topsan.org NA
Sequence family:
COG http://www.ncbi.nlm.nih.gov/COG/ 66 genomes
Pfam http://pfam.sanger.ac.uk 12,273 families
PRINTS http://www.bioinf.man.ac.uk/dbbrowser/PRINTS/ 12,121 sites
iProClass http://pir.georgetown.edu/iproclass/ 18,492,417 entries
ProDom http://prodom.prabi.fr/prodom/current/html/home.php 2,001,128 sequences
PROSITE http://prosite.expasy.org 1620 entries
SMART http://smart.embl-heidelberg.de > 500 domain families
Structure family:
AutoPSI http://services.bio.ifi.lmu.de:1046/AutoPSIDB/ NA
CATH http://www.cathdb.info 152,920 domains
CDD http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml NA
CE http://cl.sdsc.edu/ce.html NA
CL http://cl.sdsc.edu/cl1.html NA
FSSP http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-page+LibInfo+-id+5Ti2u1RffMj+-lib+FSSP 2860 folds
HOMSTRAD http://tardis.nibio.go.jp/homstrad/ 1032 families
MODBASE http://modbase.compbio.ucsf.edu 3,497,441 proteins
PartsList http://bioinfo.mbb.yale.edu/align/ NA
PDBe http://www.ebi.ac.uk/pdbe/ 75,694 entries
SCOP http://scop.mrc-lmb.cam.ac.uk/scop/ 110,800 domains
VAST http://www.ncbi.nlm.nih.gov/Structure/ NA
Function family:
AARSDB http://www.man.poznan.pl/aars/ NA
ASD http://mdl.shsmu.edu.cn/ASD/ 336 allosteric proteins
ASPD http://wwwmgs.bionet.nsc.ru/mgs/gnw/aspd/ NA
BRENDA http://www.brenda-enzymes.org 5373 enzymes
Catalytic Site Atlas http://www.ebi.ac.uk/thornton-srv/databases/CSA/ 26,846 entries
DAVID http://david.abcc.ncifcrf.gov NA
EF-hand CaBP http://structbio.vanderbilt.edu/cabp_database/ NA
EcoCyc http://ecocyc.org NA
ENZYME http://enzyme.expasy.org 4579 entries
Gene Ontology (GO) http://geneontology.org NA
GPCRDB http://www.gpcr.org/7tm/ 42,110 proteins
Homeobox Page http://www.biosci.ki.se/groups/tbu/homeo.html NA
KEGG http://www.genome.ad.jp/kegg/ NA
Laminin Database http://www.lm.lncc.br NA
MatrixDB http://matrixdb.ibcp.fr NA
MEROPS (peptidase) http://merops.sanger.ac.uk NA
MetaCyc http://metacyc.org 1747 pathways
P2CS http://www.p2cs.org 81,988 proteins
PREX http://www.csb.wfu.edu/prex/ NA
Protein Kinase Resource (PKR) http://pkr.genomics.purdue.edu NA
Protein Ontology http://pir.georgetown.edu/pro/ NA
RNase P http://www.mbio.ncsu.edu/RNaseP/home.html NA
SuperCYP http://bioinformatics.charite.de/supercyp/ 2,785 Cytochrome-Drug interactions
TransportDB http://www.membranetransport.org 365 species
Wnt gene Homepage http://www.stanford.edu/group/nusselab/cgi-bin/wnt/ NA
Modifications:
CPLA http://cpla.biocuckoo.org 7,151 lysine acetylation sites
O-GlycBase http://www.cbs.dtu.dk/databases/OGLYCBASE/ 2413 O-glycosylation sites
P3DB http://p3db.org 31,019 phosphosites
Phospho3D http://www.phospho3d.org NA
Phospho.ELM http://phospho.elm.eu.org >42,500 phosphosites
PHOSIDA http://www.phosida.com 80,062 sites
Localization:
Centrosome:db http://centrosome.dacya.ucm.es NA
eSLDB http://gpcr.biocomp.unibo.it/esldb NA
LOCATE http://locate.imb.uq.edu.au >100,000 proteins
MiCroKit http://microkit.biocuckoo.org 1,489 proteins
NPD http://npd.hgu.mrc.ac.uk >1000 proteins
NURSA http://www.nursa.org NA
Organelle DB http://organelledb.lsi.umich.edu 50 organelles
ORGe http://drake.mcmaster.ca/ogre/ 1244 metazoan organisms
PSORTdb http://db.psort.org NA
SUBA http://suba.plantenergy.uwa.edu.au 14,258 entries
PeroxisomeDB http://www.peroxisomedb.org 2819 proteins
Binding and Interaction:
3D Complex http://supfam.mrc-lmb.cam.ac.uk/elevy/3dcomplex/Home.cgi >30,000 structures
3DID http://3did.irbbarcelona.org 174,006 proteins
BindingDB http://www.bindingdb.org 781,982 binding data
BioGRID http://thebiogrid.org 409,299 interactions
BISC http://bisc.cse.ucsc.edu NA
DIMA http://webclu.bio.wzw.tum.de/dima/ NA
DIP http://dip.doe-mbi.ucla.edu 71,276 interactions
DOMINE http://domine.utdallas.edu 26,219 domain-domain interactions
DOMMINO http://dommino.org 55,650 interactions
IBIS http://www.ncbi.nlm.nih.gov/Structure/ibis/ibis.cgi 192,213 protein-protein interactions
MIPS http://www.helmholtz-muenchen.de/en/ibis NA
PIBASE http://modbase.compbio.ucsf.edu/pibase 755,998 interfaces
Protein3D Home http://protein3d.ncifcrf.gov/tsai/ NA
ReLiBase http://relibase.rutgers.edu NA
SCOPPI http://www.scoppi.org 15,058 interfaces
String http://string-db.org 5,214,234 proteins
Energetics:
3D-footprint http://floresta.eead.csic.es/3dfootprint/ 2864 complexes
eF-site http://ef-site.protein.osaka-u.ac.jp/eF-site/ 427,984 entries
KineticDB http://KineticDB.protres.ru/db/index.pl NA
ProTherm http://gibk26.bio.kyutech.ac.jp/jouhou/Protherm/protherm.html 14,500 entries
References:
MEDLINE http://www.ncbi.nlm.nih.gov/PubMed/ >21,000,000 citations
iProLINK http://pir.georgetown.edu/pirwww/iprolink/ NA
Combined:
BioSystems http://www.ncbi.nlm.nih.gov/biosystems NA
Entrez http://www.ncbi.nlm.nih.gov/Entrez/ NA
SRS http://srs.ebi.ac.uk NA
a

NA, size not available at time of printing. The data are as of September 2011.