Table 4. Haplotype-based association study.
| |
|
Frequency |
Permutation P |
|||||
|---|---|---|---|---|---|---|---|---|
| Index | Haplotype | Overall | PCV | tAMD | Control | PCV versus control | tAMD versus control | PCV versus tAMD |
| H1 |
T-T-T-T |
0.32 |
0.26 |
0.38 |
0.28 |
0.45 |
0.01 |
0.001 |
| H2 |
T-T-T-A |
0.28 |
0.28 |
0.28 |
0.27 |
0.82 |
0.8 |
0.97 |
| H3 |
T-C-A-A |
0.19 |
0.21 |
0.17 |
0.21 |
0.85 |
0.27 |
0.2 |
| H4 |
C-C-A-A |
0.15 |
0.14 |
0.11 |
0.19 |
0.06 |
0.005 |
0.25 |
| H5 | T-C-T-A | 0.05 | 0.11 | 0.06 | 0.05 | 0.001 | 0.63 | 0.018 |
Selected SNPs are rs10499862/rs3173798/rs3211883/rs3173800. SNP: single nucleotide polymorphism, PCV: polypoidal choroidal vasculopathy, tAMD: typical neovascular AMD.