Table 1.
The regions showing post-EA effects.
Resting state (CV4)—True RS | Resting state (CV12)—True RS | CV4 versus CV12 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Region (BA) | Lt (MNI Coordinate) | T value | Rt (MNI) | T | Lt (MNI) | T | Rt (MNI) | T | Lt (MNI) | T | Rt (MNI) | T |
MPF BA10/11 | −12, 48, −8 | 4.8 | 8, 48, −14 | 5.9 | −4, 44, −14 | 4.5 | 6, 48, −10 | 3.32 | ||||
Orbital F BA11/12 | 16, 48, −12 | 5.67 | 18, 48, −12 | 3.09 | ||||||||
Ventra ACC BA24/32 | −6, 44, −4 | 4.3 | 4, 40, −10 | 5.32 | −8, 40, 2 | 3.8 | 6, 34, −12 | 4.54 | ||||
BA25 | −8, 12, −12 | 2.8 | 2, 14, −14 | 3 | −6, 18, −18 | 2.8 | 4, 10, −14 | 2.34 | ||||
FP BA10 | −16, 60, 10 | 2.1 | ||||||||||
Hypothalamus | 2, 4, −12 | 2.76 | ||||||||||
Hp, HP | −34, −30, −8 | 3.5 | 18, −14, −20 | 2.01 | −40, −28, −18 | 3.8 | ||||||
Amygdala | 24, −8, −20 | 2.5 | 24, −8, −20 | 2.34 | ||||||||
TP | 38, 18, −42 | 3.24 | ||||||||||
SN | 14, −12, −10 | 2.14 | 14, −12, −12 | 2.49 | ||||||||
PCC BA | −10, −72, 50 | 1.88 | ||||||||||
LMF BA | −38, 24, 40 | 2.8 | −24, 20, 42 | 2.6 | ||||||||
Marginal gyrus BA40 | 54, −32, 38 | 2.67 | 44, −34, 22 | 2.6 | ||||||||
PAG | −6, −34, −8 | 2.7 | −4, −36, −8 | 2.46 | ||||||||
Cerebellum | −10, −46, −58 | 3.7 | −8, −76, −35 | 2.71 |
Note. (for CV4, n = 20, for CV12, n = 18, P < 0.05/T > 1.3) True RS (resting state): The resting state session before sham EA.
MPF: medial prefrontal cortex, Orbital F: orbital frontal cortex, Ventra ACC: ventral anterior cingulate cortex, FP: frontal pole, HP: hippocampus, ParaHP: parahippocampus, TP: temporal pole, SN: substantial nigra, PCC: posterior cingulate cortex, LMF: lateral middle frontal cortex, and PAG: periaqueductal gray matter.
The brain regions showing enhanced post-EA local connectivity were similar for two acupoints: medial prefrontal cortex BA10/11, anteroinferior portion of the anterior cingulate cortex BA24/32, BA25, followed by hippocampus, parahippocampus. Differences were seen in Amygdala and Marginal gyrus, BA40 (CV4 > CV12).