Table 1.
Expression profile of ligands and receptors of human tumor necrosis factor superfamily
| Symbol | Ligand (alias) | Cellular expression | Symbol | Receptor (alias) | Cellular expression |
|---|---|---|---|---|---|
| TNFSF1 | TNF-β (LT-α) | NK, T, and B cells | TNFRSF1A | TNFR1 (DR1) | Hematopoietic and immune cells |
| TNFRSF1B | TNFR2 | Immune and endothelial cells | |||
| TNFSF2 | TNF-α | Macrophages and NK, T, and B cells | TNFRSF1A/B | TNFR1/2 | Immune and endothelial cells |
| TNFSF3 | LT-β | Activated CD4+ T cells and T, DC, and NK cells | TNFRSF3 | LT-βR | NK cells, CD4+ and CD8+ T cells |
| TNFSF4 | OX40L (CD252, gp34) | B and T cells, DCs, endothelial and smooth muscle cells | TNFRSF4 | OX40 (CD134) | Activated CD4+ T cells and neutrophils |
| TNFSF5 | CD40L (CD154, gp39) | Activated CD4+ T lymphocytes, NK cells, mast cells, basophils, and eosinophils | TNFRSF5 | CD40 (p50) | B cells, monocytes, DCs, and thymic epithelium, Reed-Sternberg cells |
| TNFSF6 | FasL (CD95L, Apo1L) | Activated splenocytes, thymocytes, nonlymphoid tissues, and NK cells | TNFRSF6 | Fas (CD95, Apo1, DR2) | Epithelial cells, hepatocytes, activated mature lymphocytes, and transformed cells |
| TNFRSF6B | DcR3 | Lung and colon cells | |||
| TNFSF7 | CD27L (CD70) | NK, T, B, and mast cells, smooth muscle and thymic epithelial cells | TNFRSF7 | CD27 | Hematopoietic progenitors, and CD4+ and CD8+T cells |
| TNFSF8 | CD30L (CD153) | Activated T cells, B cells, and monocytes, granulocytes, and medullary thymic epithelial cells | TNFRSF8 | CD30 | Reed-Sternberg cells |
| TNFSF9 | 4–1BBL | APCs (B cells, macrophages, and DCs), mast cells | TNFRSF9 | 4–1BB (CD137, ILA) | T, NK, and mast cells, and neutrophils |
| TNFSF10 | TRAIL (Apo2L) | NK and T cells, DCs | TNFRSF10A | TRAILR1 (DR4, Apo2) | Most normal and transformed cells |
| TNFRSF10B | TRAILR2 (DR5) | Most normal and transformed cells | |||
| TNFRSF10C | TRAILR3 (DcR1) | Most normal and transformed cells | |||
| TNFRSF10D | TRAILR4 (DcR2) | Most normal and transformed cells | |||
| TNFRSF11B | OPG (OCIF) | Most normal and transformed cells | |||
| TNFSF11 | RANKL (TRANCE, OPGL, ODF) | T cells, thymus, and lymph nodes | TNFRSF11A | RANK (TRANCER) | Osteoclasts, osteoblasts, and activated T cells |
| TNFRSF11B | OPG (OCIF) | Osteoclast precursors, endothelial cells, and others | |||
| TNFSF12 | TWEAK (Apo3L) | Monocytes | TNFRSF12A | TWEAKR (FN14) | Endothelial cells and fibroblasts |
| TNFSF13 | APRIL (TALL-2, TRDL-1) | Macrophages, lymphoid cells, and tumor cells | TNFRSF13A/17 | BCMA | B cells, PBLs, spleen, thymus, lymph nodes, liver, and adrenals |
| TNFRSF13B | TACI | B cells, activated T cells, PBLs, spleen, thymus, and small intestine | |||
| TNFSF13B | BAFF (BLYS, THANK) | T cells, monocytes, macrophages, and DCs | TNFRSF13B | TACI | B cells, activated T cells, PBLs, spleen, thymus, and small intestine |
| TNFRSF13C | BAFFR | B cells, resting T cells, PBLs, spleen, lymph nodes | |||
| TNFRSF17 | BCMA | B cells, resting T cells, PBLs, spleen, lymph nodes | |||
| TNFSF14 | LIGHT (HVEML, LT-γ) | T cells, granulocytes, monocytes, and DCs | TNFRSF14 | LIGHTR (HVEM) | T and B cells, monocytes, and lymphoid cells |
| TNFRSF3 | LT-βR | Nonlymphoid hematopoietic and stromal cells | |||
| TNFSF15 | VEGI (TL1A) | Endothelial cells | TNFRSF25 | DR3 | NK cells, CD4+ and CD8+ T cells |
| APCs (B cells, macrophages, and DCs) | TNFRSF6B | DcR3 | Activated T cells | ||
| TNFSF18 | GITRL | HUVECs | TNFRSF18 | GITR (AITR) | CD4+CD25+ T cells |
| EDA-A1 | Skin | EDAR | Ectodermal derivative | ||
| EDA-A2 | Skin | XEDAR | Ectodermal derivative, embryonic hair follicles | ||
| NI | TNFRSF19 | TROY (TAJ) | Embryo skin, epithelium, hair follicles, and brain | ||
| NI | TNFRSF19L | RELT | Lymphoid tissues, hematopoietic tissues | ||
| NI | TNFRSF21 | DR6 | Resting T cells | ||
| NI | TNFRSF16 | NGFR (CD271) | Neuronal axons, Schwann cells, perineural cells |
NI indicates not identified; OX40L, OX40 ligand; Fas, fibroblast-associated; TRANCE, TNF-related activation-induced cytokines; OPGL, OPG ligand; ODF, osteoclast differentiation factor; TALL, TNF- and APOL-related leukocyte expressed ligand; TRDL, TNF-related death ligand; HVEM, herpesvirus entry mediator; GITR, glucocorticoid-induced TND receptor; APCs, antigen-presenting cells; HUVECs, human umbilical vein endothelial cells; ILA, induced by lymphocyte activation; OCIF, osteoclastogenesis inhibitory factor; FN14, fibroblast growth factor-inducible immediate-early response gene 14; PBLs, peripheral blood lymphocytes; AITR, activation-inducible TNF receptor superfamily member; XEDAR, X-linked ectodysplasin receptor; TROY, TNFRSF expressed on the mouse embryo; TAJ, toxicity and JNK inducer; RELT, receptor expressed in lymphoid tissues; and NGFR, nerve growth factor receptor.