Table 1.
Overview of the composition of bispecific adapters used to reroute viruses for oncolytic purposes.
| Adaptor protein moiety binding to | Targeting demonstrated for | |
|---|---|---|
| Virion | Cell | |
| Antibody (scFv or Fab) | Antibody (scFv or Fab) | Adenovirus |
| Adenoassociated virus | ||
| Coronavirus | ||
| Antibody (scFv or Fab) | Ligand peptide | Adenovirus |
| Paramyxovirus | ||
|
| ||
| Soluble/pseudo receptor | Antibody (scFv or Fab) | Adenovirus |
| Herpesvirus | ||
| Coronavirus | ||
| Soluble/pseudo receptor | Ligand peptide | Adenovirus |
| Coronavirus | ||
|
| ||
| Polymer | Antibody (scFv or Fab) | Adenovirus |
| Polymer | Ligand peptide | Adenovirus |