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Cisplatin half-life (■) and the corresponding percent of increased lifespan (%ILS) (gray square) from the P388 murine lymphocytic leukemia model are plotted as a function of the liposomal membrane composition. Mice (n = 8) bearing P388 tumors received intravenous injections of liposomal cisplatin formulations at MTD doses on a Q4D × 3 dosing schedule.
