Table 1.
Epidemiological studies of HPC.
| Study, year [ref] | Type | Location | No. of patients | Findings |
|---|---|---|---|---|
| Falk, 1988 [9] | Case control | Louisiana, USA | 363 | OR 5.25 if FH |
|
| ||||
| Lynch, 1990 [10] | Descriptive | Nebraska, USA | 47 | 10-fold increased occurrence of PC if FH of PC (7.8% versus 0.6%) |
|
| ||||
| Ghadirian, 1991 [11] | Case control | Montréal, Canada | 179 | 13-fold increased occurrence of PC if FH of PC (6.7% versus 0.7%) |
|
| ||||
| Fernandez, 1994 [12] | Case control | Italy | 362 | 4-fold increased occurrence of PC if FH of PC (3.9% versus 1.1%); RR 3 if FH |
|
| ||||
| Dergham, 1997 [13] | Case series | Detroit, USA | 81 | 9% occurrence of PC if FH of PC. |
|
| ||||
| Coughlin, 2000 [14] | Cohort | USA | 3751 | RR 1.5 (men)–1.7 (women) if FH |
|
| ||||
| Hemminki, 2003 [15] | Cohort | Sweden | 21,000 | SIR 2.4 if FH (parent) |
|
| ||||
| Klein, 2004 [16] | Registry | Baltimore, USA | 5179 | SIR 32 if 3 FDR with PCSIR 6.4 if 2 FDR with PCSIR 4.5 if 1 FDR with PC |
|
| ||||
| Permuth-Wey, 2008 [17] | Meta-analysis | USA, Italy, Canada, Japan | 6568 | RR 3.4 if FH of PC |
OR: odds ratio; RR: relative risk; SIR: standardized incidence ratio; FH: family history; FDR: first-degree relative.