Table 1.
Effects of drugs and plant extracts against P. falciparum strains DD2 (A) and 3D7 (B) infection in RBCs.
| Drug | EC50 μg/mL | EC90 μg/mL | CC50 μg/mL | SI (CC50/EC50) | |
|---|---|---|---|---|---|
| (A) | Sigma CQa∗ | 10.0 | 20.4 | NA | NA |
| Sigma CQb∗ | 21.0 | 77.9 | 82.7 | 3.9 | |
| Formulated CQb | 32.6 | >50c | >50c | >1.5 | |
| GHX-6Lb | >445c | >445c | >445c | ND | |
| GHX-26Fb | 272.8 | >340c | >340c | >1.2 | |
| (B) | Formulated CQb | 0.025 | 0.05 | >50c | >2,000 |
| GHX-6Lb | >445c | >445c | >445c | ND | |
| GHX-26Fb | 4.9 | 16.2 | >340c | >69.4 |
aTested by IMT, bTested by MTT-based CSA, *Parasitemia used was 1.5%. For the other tests, parasitemia used was 3.0%, cHighest concentration tested, SI: selective index, NA: not applicable, ND: not determined.